Immunology of paracoccidioidomycosis.
نویسندگان
چکیده
Paracoccidioidomycosis is the most prevalent systemic mycosis in Latin America, among immunecompetent patients. It's caused by the dimorphic fungus Paracoccidioiddes brasiliensis. Investigations regarding its immunopathogenesis are very important in the understanding of aspects related to natural history, as the protective immunity, and the relationship between host and parasite; also favoring the knowledge about clinical patterns and the elaboration of therapeutic strategies. The disease clinical polymorphism depends, at least, of the immune response profile according to the tissue and blood released citokynes, resulting in tissue damage.
منابع مشابه
Altered ex vivo expression of caspase 8, caspase 9, and Bcl-2 is associated with T-cell hyporeactivity in patients with paracoccidioidomycosis.
To better understand the T-cell hyporesponsiveness of patients with paracoccidioidomycosis, we tested the hypothesis that the T cells were committed to apoptosis. We show here that T cells of patients with paracoccidioidomycosis overexpress caspase 9 and caspase 8 but express low Bcl-2 levels and that interleukin-2 was unable to revert the hyporesponsiveness. These data suggest that the T cells...
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عنوان ژورنال:
- Anais brasileiros de dermatologia
دوره 86 3 شماره
صفحات -
تاریخ انتشار 2011